The area most significantly subjected to the ecological principles suggested by park (invasion, domination, etc.) is

Answer;
Zone II
The area most significantly subjected to the ecological principles suggested by park is Zone II.

Explanation;
Zone II also the zone in transition, is appropriately named since it was truly in a state of transition from residential to industrial, primarily because it was the area of the city in which businesses and  factories were invading residential areas. was the area that was most significantly subjected to the ecological principles, Park suggested: invasion, domination, recession, and succession. 

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