fSickle cell anemia is a condition where the red blood cells are deformed, and the transportation of oxygen is affected in this condition.
Sickle cell anemia is a kind of anemia that can be inherited. In this condition, there is no adequate amount of red blood cell which carries oxygen in the body. In a normal individual red blood cell round, flexible and can move easily through the vessels. On the other hand, if an individual is suffering from sickle cell anemia, his/her red blood cell becomes sticky, rigid, and shaped similar to crescent or sickle. These crescents shaped RBC get trapped in vessels, which lock or slow down the flow of blood and unable to provide oxygen. Sickle cell anemia cannot be easily treated, but medicines can provide relief in the pain.
The major sign of sickle cell anemia:Anemia Pain Swelling of feet and hand Frequent infections. Problem in vision
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Grade: High School
Anemia, sickle cell, vision, swelling, sickle cell, crescent shape, pain, feet, hand, infection, oxygen, body, red blood cell, frequent.
Missense mutation is a type of mutation in which there is a change in a single nucleotide in a DNA sequence. It is a point mutation because only one single nucleotide is substituted or replaced by another. This change in a single nucleotide in a DNA sequence results to a change in the mRNA sequence produced from the DNA and this will lead to the incorporation of a wrong amino acid in the polypeptide chain of the protein. Missense mutation leads to a change in one codon in an mRNA which will lead to the production of a protein with an amino acid sequence that is different from the original protein. A missense mutation often leads to the production of a nonfunctional protein
Sickle cell anemia is caused by an abnormal hemoglobin in red blood cells. hemoglobin is the red pigment found in red blood cells for carrying oxygen.
The abnormality arises from a genetic mutation in the DNA gene that codes for the beta chain of the protein called globin of which hemoglobin is made of.
In the beta chain, the sixth amino acid called glutamine is replaced by another one called valine.
This one change in the amino acids cause the hemoglobin protein to behave abnormally, causing red blood cells to lose their normal spherical shape and become bent like a sickle, hence the name "sickle cell" anemia
A genetic disorder in which the deformation of red blood cells occurs due to which transportation of oxygen is hindered is called sickle cell anemia.
The inherited form of anemia is sickle cell anemia. It is a condition during which the body contains an inadequate amount of red blood cells to fulfill the required supply of oxygen in the body. The normal red blood cells are round and flexible and move with ease through the blood vessels. The defective red blood cells during sickle cell anemia appear like a crescent moon and become sticky and rigid. These defective cells cannot pass the blood vessels and get stuck in between. It may lead to a stoppage and slow down of blood flow, which in turn also obstructs the passage of oxygen throughout the body.
The gene mutation is the cause of the anemia. This gene is responsible for the production of haemoglobin. Haemoglobin is an iron-rich compound which provides the blood with its red color. The red blood cells carry oxygen with the help of hemoglobin, which binds oxygen. Abnormal hemoglobin is produced during sickle cell anemia, which makes the red blood cells rigid and sticky.
These defective genes are passed from parents to the offspring and generate an inheritance pattern, which is called autosomal recessive inheritance. This means both the parents must transfer the defective allele to produce an affected child. If a person inherits a sickle cell gene from only one parent, he/she is a carrier of the disease. This implies that the person can further pass on the gene to his/her progeny.
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Grade: High School
Chapter: Sickle Cell Anaemia
Anemia, sickle cell anemia, red blood cells, oxygen, hemoglobin, blood vessels, mutation, inheritance pattern, autosomal recessive, iron-rich compound, blood, allele, gene.
Sickle cell anemia is defined as a genetically inherited disorder that causes deformation of red blood cells (RBCs) and inadequate oxygen transport. It is caused by a mutation in the gene that encodes for hemoglobin and leads to formation of a defective protein.
The RBCs transport oxygen to the various parts of body with the help of hemoglobin molecules. Due to defective hemoglobin, blood cells become sticky and rigid, and shape like sickles. The resulting sickle-shaped cells get stuck in blood capillaries that block or slow down blood flow or oxygen transport to the body organs.
Thus, 'sickle cell anemia affects oxygen transport in the body.'
Any and all major organs are affected by sickle cell disease. The liver, heart, kidneys, gallbladder, eyes, bones, and joints can suffer damage from the abnormal function of the sickle cells and their inability to flow through the small blood vessels correctly. Let me know if this helps! Please rate my answer so I know how I'm doing! xx
Explanation:I just did this question and I got it right, so that’s how I know it’s right lol.
Question 1. The best answer is C - antigen on the red blood.
The ABO blood classification is based on the red blood cells. In summary:
1. blood type A has antigen A on the red cell membrane.
2. blood type B has antigen B on the red cell membrane.
3. blood type AB has both antigen A and B on the cell membrane.
4. blood type O has no antigen at all on the red cell membrane.
Question 2. the best answer is b - transportation of oxygen.
Sickle cells have an abnormal type of hemoglobin that is unable to carry oxygen in the same capacity that normal, healthy hemoglobin does.
Sickle cell anemia is a hereditary disease which provides less oxygen to cells due to a change in the shape of red blood cells which fails to carry oxygen to cells.
In sickle cell anemia, the effected or mutated part is the beta gene that normally makes hemoglobin but due to the mutation in the amino acid, the protein formed is defected and fails to perform its normal function.
As mentioned above, it is a heredity diseases and pass from generations to generations.