Complete a fish-bone chart detailing reasons why an airline customer might be dissatisfied.

Warmer ocean surface water would most likely be found near

Mr. j, age 42, is a construction worker in las vegas. he recently noticed that a mole on his face seemed to be getting larger and darker. at first he did not worry because he was in the sun a lot and assumed the change may have been caused by sunburn. after a month, not only was the mole larger and darker, but it appeared to be “bumpy.” his doctor diagnosed a malignant melanoma skin cancer following biopsy of the nevus. mr. j reports pain in his right shin that does not go away when he puts his feet up or sleeps. discussion questions 1. relate mr. j’s skin changes to the warning signs for malignant melanoma. (see malignant melanoma.) 2. discuss the normal progression of this malignancy. what is the significance of the bone pain that mr. j is experiencing? (see malignant melanoma.) 3. discuss the treatment available for this patient and the prognosis for recovery. (see malignant melanoma.)

1. an enzyme is considered a(n) because it speeds up a chemical reaction without being used up.2. in a catalyzed reaction, a reactant is often called a(n) . an enzyme is specific because the shape of its matches only particular reactants.4. an enzyme speeds up reactions by lowering the . the between an active site and its substrate often strains bonds and the reaction proceed.6. a( , which is often a vitamin, binds to an enzyme and plays a role in catalysis.7. high temperatures or changes in ph can an enzyme, causing it to lose its shape and biological activity.