What are three different defects that could be responsible for malfunctioning lysosomes?
select the three correct answers.
a) a defect in the synthesis of the glucose-6-phosphate dehydrogenase
b) a defect in the mannose-6-phosphate receptor in the golgi apparatus
c) a defect in the releasing small molecules from digested materials into the cytosol
d) a defect in a hydrolytic enzyme that breaks down polysaccharide
e) a defect in the process of adding a mannose-6-phosphate signal to lysosomal hydrolases
f) a defect in the mannose-6-phosphate receptor in the mitochondria

B); D) and E)

Explanation:

B) a defect in the mannose-6-phosphate receptor in the Golgi apparatus.

Explanation: The mannose-6-phosphate receptors (MPR's) in the Golgi apparatus are essential for targeting the mannose-6-phosphate tagged lysosomal proteins to the lysosome.

D) a defect in a hydrolytic enzyme that breaks down polysaccharide.

Explanation: Lysosomes contain enzymes that hydrolyze polysaccharides, therefore any defects in these enzymes causes malfunctioning of the lysosome.

E) a defect in the process of adding a mannose-6-phosphate signal to lysosomal hydrolases.

Explanation: In the Golgi apparatus lysosomal proteins are tagged with mannose-6-phosphate so that they are specifically transported to the lysosomes.  

before, trains worked using the steam engine. thus, it uses heat so it is crucial to apply heat balance. the steam engine absorbs energy during the stage of boiling water. so, this is the endothermic reaction. when the steam is used to work the piston, it has to release this energy through running the train. the excess energy is released as an exhaust to the chimney. this is the exothermic process because it releases energy to the surroundings.