The quantitative differences in biological activity between the two enantiomers of a compound are sometimes quite large. for example, the d isomer of the drug isoproterenol, used to treat mild asthma, is 50 to 80 times more effective as a bronchodilator than the l isomer. identify the chiral center in isoproterenol. why do the two enantiomers have such radically different bioactivity?

The Chiral center is show in the figure

Explanation:

If a carbon atom is bonded to four differents groups as in isoproterenol (-OH, -Ph, -H and -CH2-R), it is a chiral carbon, which means that the molecule has two enantiomers, D and L.

Each enantiomer will have a different bioactivity, the bioctivity is the interaction of the D or L enantiomer with a biological receptor which also is chiral. The two enantiomers have different bioactivity because each one interact  different with the biological receptor.

a mercury barometer is a device that uses the physical properties of mercury in a tube to measure barometric pressure. mercury barometers are used for : -

1. measurement of atmospheric pressure  

2. determining the altitude of a place

3. weather forecasting

4. calibration and checking of aneroid barometers

5. application in fluid mechanics

6. measurement of pressure in aircrafts

7. surface weather analysis

8. preparation of barographs

9. usage in physical sciences like physics, astronomy & chemistry

10. preparation of aircraft altimeters

characteristics of mercury barometer : -

1.used to define and measure atmospheric pressure.

2.on the average at sea level the column of mercury rises to a height of about 760 mm.

3.this quantity is equal to 1 atmosphere.

4.it is also known as standard atmospheric pressure.

5.a barometer in which the weight of a column of mercury in a glass tube with a sealed top is balanced against that of the atmosphere pressing on an exposed cistern of mercury at the base of the mercury column, the height of the column varying with atmospheric pressure.

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