By what year did the Ottoman Empire first expand into parts of North Africa? 1451
1520
1566
1683

Considering most dates aren't accurate the answer would be 1566

Explanation: The Ottoman naval recovery persuaded Venice to sign a peace treaty in 1573, and the Ottomans were able to expand and consolidate their position in North Africa. The Ottomans suffered reverses to their power in the Mediterranean with their failure to capture the island of Malta from a comparatively small group of Christian knights (1565), and in the defeat of their navy at the hands of a Christian fleet at the battle of Lepanto (1571). They also experienced some significant reverses against Persia, in the east. Ottoman expansion in North Africa continued, however, and much territory was recovered from the Persians in 1639.

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answer; ewing's sarcoma;