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C
An effect of the Kansas-Nebraska Act of 1854 was that
the Democratic Party was formed.
the Missouri Compromise was passed.
Senator Stephen Douglas was elected.
the Republican Party was formed.

I think it’s the Missouri compromise was passed

Explanation:

the secretary of state, appointed by the president with the advice and consent of the senate, is the president's chief foreign affairs adviser. the secretary carries out the president's foreign policies through the state department and the foreign service of the united states.