In his work, we can see the humanistic values of ancient Greece and Rome. El Greco's work was the work of the past. In his work, we can see his humanistic viewing of the renaissance. He was painting Christ and portraits of the humanist people. He was pointing to two worlds, the real (Earth) and the spiritual world Heaven blended with imagination and expressions of feelings and tension. He was the most influenced where humanism has flourished at that time. El Greco revealed him as an intellectually curious spirit, strongly inclined to history, enthusiastic about literature, politics, philosophy, and even medicine, characteristic of a Renaissance humanist. Painter of Cretan origin based in Spain, Domenikos Theotokopoulos, born in 1541 and decreased in 1614, received a humanist education, which justifies the interest he has always shown in the most varied fields of thought and art. After a formation in Venice and Rome, he finally settled in Toledo in 1577. Surrounded by an excellent artistic reputation, various works for the churches and convents of Toledo: The Estate (1579), The Baptism Christ (1595-1600), The Christ in the Garden of Olives (1605-10), The Resurrection (1608-10), which did not prevent the untraditional treatment of the issues from causing controversy among the ecclesiastical authorities. In addition to religious themes, he painted portraits of personalities of Spanish life and city landscapes, presenting them in dramatic light. In his work can be found the Byzantine mysticism, Titian's sensitivity to color and play of light, Tintoretto's conception of space, the distortions and positions of Mannerism, and the mix of realism and fantastic present in the Spanish religious atmosphere. In his latest works, notably in Vision of Revelation (circa 1610), the environment of spiritual fervor creates a pictorial force that reaches an expressionist dimension.