The significance of the septum of the human heart is most closely related to keeping blue blood and red blood separate keeping oxygenated and deoxygenated blood separate providing enough muscle power to circulate blood sending blood to the four limbs

Keeping oxygenated and deoxygenated blood separate The interventricular or ventricular septum is located at the mid-portion of the heart. It is responsible for keeping the oxygenated blood from the left portion of the heart from the deoxygenated blood from the right portion of the heart from mixing and combining together. It helps to secure the heart and increase the pushing of the red blood cells to the other valves.