With respect to acetylcholine, botox is to nicotine as is to

antagonist to agonist

Explanation:

Glutamate has excitory effect on the nerve fibres in the central nervous system. It is mostly found in synaptic vesicle of nerves terminals in abundance and can be released through exocytosis. The glutamate has special transporters on the plasma membrane that allow it to be transported across neurons.

A drug increases the effect of the neurotransmitter is called an agonist. If it decreases the effect of the neurotransmitter it is called an antagonist. If the neurotransmitter is excitatory like glutamate above, nicotine presence will increase the excitatory effect, and presence of botox will decrease the excitatory effect by inhibit its diffusion across the neurone.

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explanation:

because i added numbers