Binding of glucose to hexokinase causes a conformational change in the enzyme. this is an example of the model of enzyme catalysis.

Binding of glucose to hexokinase causes a conformational change in the enzyme. This is an example of the induce-fit model of enzyme catalysis.

Explanation:

The induce- fit model is generally the most accepted theory for enzyme catalysis. This theory states that the active site of an enzyme is not always a perfect fit for a substrate. The substrate induces changes in the active site so that it can fit into the active site. This theory is contrary to the theory of lock and key model, which stated that substrates exist as a perfect match for particular active sites of an enzyme.

substitution is the answer in this case