The combination of tobacco use and intake greatly increases risk for oral cancers.

The given blank can be filled with alcohol.  

Alcohol and tobacco are the most important oropharyngeal cancer and oral cavity risk elements. Mouth cancer is basically a lifestyle disorder, signifying that the majority of cases are associated with alcohol and tobacco use.  

About 90 percent of individuals with mouth cancer are tobacco users. The individuals who cease the use of tobacco, even after many years of use, can largely minimize their threat of all smoking-associated conditions like mouth cancer.  

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