What aspects of gas giants is most responsible for their low temperatures

Their distance from the sun

Explanation:

Temperatures on gas giants are low because they are at a great distance from the sun and do not endure as much energy as terrestrial planets. Besides, of all the gas giants, Jupiter is closest to the sun; in contrast to Neptune, which is the furthest from the sun and has the longest period of revolution.  

the cytokine-activated janus kinase (jak)-signal transducer and activator of transcription (stat) pathway has an important role in the control of immune responses. dysregulation of jak-stat signaling is associated with various immune disorders.