Some antacid drugs block histamine receptors, resulting in reduction of the production and excretion of stomach acid. these drugs have the biggest effect on which of the following?

a) parietal cells
b) mucous neck cells
c) surface epithelial cells
d) chief cells

A) parietal cells

Explanation:

Parietal cells are the epithelial cells of the stomach that have the function to secrete hydrochloric acid (HCl) and intrinsic factor. Parietal cells contain canaliculi – secretory network for the secretion of HCl via active transport.

Parietal cells are regulated via several factors such as acetylcholine, gastrin and histamine. So, if histamine receptors are blocked via antacid drugs , the secretion of the acid will be reduced.

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