Which of the following observations supports the statement that cytomegalovirus (cmv) has a remarkably broad tropism? which of the following observations supports the statement that cytomegalovirus (cmv) has a remarkably broad tropism? different strains of cmv have been shown to infect humans, rodents, and rhesus monkeys. cmv is a universally distributed pathogen, with approximately 40-100% of the world's population having shown immunological evidence of infection. cmv can infect connective tissue cells and parenchymal cells of virtually any organ. infection with cmv can occur through various portals of entry, including genitourinary, vertical transmission, and direct contact with infectious tissues, secretions, or excretions.