Pam, who has sickle cell anemia, is married to jim, who is healthy. jim’s parents are also healthy and he has two older sisters and an older brother; all healthy individuals. pam’s parents are healthy as is one of her younger brothers, but her youngest brother also has sickle cell anemia. jim and pam have a set of identical twin daughters who both have sickle cell anemia.
the prevalence of this disease is 1 in 365 african-american births in the us. estimate the genotypic frequencies in this population if the locus was in hardy-weinberg equilibrium.
based on your knowledge of this disease, do you think the population would be in hardy-weinberg equilibrium? why or why not? if not, what evolutionary force do you think would have the largest effect?