Which statement accurately describes the effect of insulin on the expression of the gene for glucose 6-phosphatase?
a. insulin activates pkb by phosphorylation, which then phosphorylates foxo-1. phosphorylation of foxo-1 causes an increase in its degradation by the proteasome, which is associated with an increase in the expression of the gene for glucose 6- phosphatase.
b. insulin leads to the activation of pkb, which then phosphorylates foxo-1. phosphorylation of foxo-1 causing an increase in its degradation by the proteasome, which is associated with a decrease in the expression of the gene for glucose 6- phosphatase.
c. insulin activates phosphoprotein phosphatase, which then dephosphorylates foxo-1. dephosphorylation of foxo-1 causes a decrease in its degradation by the proteasome and an increase in the expression of the gene for glucose 6-phosphatase.
d. insulin leads to the activation of pka, which then phosphorylates foxo-1. phosphorylation of foxo-1 causing a decrease in its degradation by the proteasome, which is associated with a decrease in the expression of the gene for glucose 6- phosphatase.
e. insulin triggers the phosphorylation of pkb, which then phosphorylates foxo-1. phosphorylation of foxo-1 causes a decrease in its degradation by the proteasome, which is associated with an increase in the expression of the gene for glucose 6- phosphatase.