Anonsense mutation in a particular gene resulted from a tgg --> tga mutation. what compensatory mutation in the anticodon of which trna would restore the protein polypeptide sequence?

Nonsense mutation is a type of mutation which results in stop codon and premature termination of translation.

In above mutation also, TGG codes for tryptophan but TGA is a stop codon.

TGG will be coded as ACC in mRNA and TGA will be coded as ACU in mRNA.

Thus, anticodon of ACC will be UGG and that of ACU will be UGA.

Thus, there should be a mutation in anticodon of tRNA UGG as it codes for tryptophan.

Its mutation to UGA will restore the normal polypeptide sequence.

you are certainly talking about this picture:

a: is the label of the white square, it is showing the  replication fork, formed by helicase (d) ==> so it is the site of dna separation and replication 

b: is a new dna brand that is following directly the replication fork, so it is continuous ==> built continuously from 5' to 3

c: dna polymerase cannot replicate dna on its own, it needs the of their proteins, and one of them plays the role of a clamp which fixes  the dna with the dna template and increases  the processivity of the enzyme. ==>   stops polymerase from falling off the  template.

d: is the enzyme responsible for forming the replication fork (helicase) ==> unwinds and separates dna into two strands

e: is the delayed strand, it is built  in the opposite sense of the helicase, so dna will be built in fragments ==> built  fragments from 5' to 3 joins

and finally f: is the enzyme that builds  the new dna strand (dna polymerase) ==>   adds nucleotides to make a new dna helix.

credit: gradman555p98x9p

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