Nonpolar amino acid residues are typically found in the interior of globular proteins like chymotrypsin. which chemical force is most directly responsible?
a. tertiary structure
b. hydrophobic interactions
c. ionic bonding
d. covalent bonding

The correct answer is B.Hydrophobic interaction

Explanation:

Non polar amino acids like glycine, proline, valine, leucine do not participate in H- bond formation with water due to neutral in nature and have to be placed in that area where they do not interact with water and that portion is the interior(core) of the globular protein.

Hydrophobic interaction is the major chemical force which is responsible for burring of non polar proteins in the center and folding of protein so that non polar amino acids do not interact with water and the protein remain stable and biologically active.

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