An enzyme is thought to optimize the fit between substrates by restraining and stretching or squeezing them into certain shapes and moving them to the transition state as described by the model of enzyme activity.

Induced fit model of the enzyme activity

Explanation:

The induced fit model of the enzyme was given in the 1894 as the lock and key model for the enzyme and substrate.

It states that the substrate acts as key to the lock of the active site. The substrate and active site of enzyme are perfect match of each other.

The enzyme finds the exact counter part during the chemical reaction. The enzyme optimizes to fit the substrate by stretching, restraining or squeezing.