Which of the following model organisms contributed the most to connecting the genetic strand and the biochemical strand of modern cell biology through the use of genetic techniques and biochemical techniques to show molecules interacting in vivo? which of the following model organisms contributed the most to connecting the genetic strand and the biochemical strand of modern cell biology through the use of genetic techniques and biochemical techniques to show molecules interacting in vivo? pea plants illustrated the behavior of trait inheritance between generations. yeast mutants and yeast two-hybrid systems allow for the characterization of genetic mutants and determination of how specific proteins interact within a living cell. mutants of drosophila melanogaster allowed for the mapping of genetic traits to particular chromosomes. yeast was used to isolate enzymes into a cell-free extract that could carry out fermentation.