How does the angle of sunlight affect the amount of energy received at earth's surface?

The amount of heat energy received at any location on the globe is a direct effect of Sun angle on climate, as the angle at which sunlight strikes the Earth varies by location, time of day, and season due to the Earth's orbit around the Sun and the Earth's rotation around its tilted axis.

an active site is a region that is present on an enzyme where the reactants or the substrate molecules we can say bind and experience a chemical reaction. the substrate is basically a reactant whose concentration is changing and that is converting into a product after binding at the active site of an enzyme