Sickle-cell anemia is a recessive autosomal disorder that is caused by an amino acid substitution in the β-hemoglobin protein. the dna mutation underlying this substitution is a snp that alters a gag codon for the amino acid glutamate to a gtg that codes a valine. the frequency of sickle-cell anemia among african americans is about 1/400. what is the frequency of this gtg codon in the β-hemoglobin gene among african americans?
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