Biology, 10.11.2019 03:31 Valfrutos2912
Enalapril is an anti-hypertension "prodrug" (i. e., a drug precursor) that is inactive until the ethyl ester (arrow in figure) is hydrolyzed by esterases present in blood plasma. the active drug is the dicarboxylic acid ("enalaprilat") that results from this hydrolysis reaction. part aenalaprilat is a competitive inhibitor of the angiotensin-converting enzyme (ace), which cleaves the blood-pressure regulating peptide angiotensin i. ace has a km = 52 μm for angiotensin i, which is present in plasma at a concentration of 75 μm. when enalaprilat is present at 2.4 nm, the activity of ace in plasma is 10% of its uninhibited activity. what is the value of ki for enalaprilat? express your answer to two significant figures and in units of m.
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Enalapril is an anti-hypertension "prodrug" (i. e., a drug precursor) that is inactive until the eth...
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