Upon their activation, receptor tyrosine kinases phosphorylate cytoplasmic substrate proteins, thereby altering
a. their ability to interact with other proteins within the cell
b. their localization
c. their actiity
d. all of the choices are correct

D. All are correct

Explanation:

Receptor tyrosine kinase help in signal transduction pathway that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands — play key roles in processes such as cellular growth, differentiation, metabolism and motility.

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