Which of the following sequences shows a frameshift mutation compared to the wild-type mrna sequence?
a) wild-type 5’-augcauacauuggaguga-3’ mutant 5’-augcaugugacauuggaguga-3’
b) wild-type 5’-augcauacauuggaguga-3’ mutant 5’-augcauacagaguga-3’
c) wild-type 5’-augcauacauuggaguga-3’ mutant 5’-augcauacguuggaguga-3’
d) wild-type 5’-augcauacauuggaguga-3’ mutant 5’-augcauacaucuggaguga-3’

D) wild-type 5’-AUGCAUACAUUGGAGUGA-3’ mutant 5’-AUGCAUACAUCUGGAGUGA-3’ is the right answer

Explanation:

frame shift mutation is that mutation in which change in nucleotide sequence ( deletion or insertion) changes the encoding amino acid sequences.

wild-type 5’-AUGCAUACAUUGGAGUGA-3 encode  MHTLE- protein sequence  while

5’-AUGCAUACAUCUGGAGUGA-3’ encode MHTSGV.

in this option there is clear difference between the encoding amino acid sequence

.in option A and B, there are addition and deletion of amino acids because of addition of nucleotide.