Which of the following would be a reasonable experimental strategy to prevent translation of a particular prokaryotic mrna without targeting the ribosome? which of the following would be a reasonable experimental strategy to prevent translation of a particular prokaryotic mrna without targeting the ribosome? inhibit termination factors. inhibit the sigma factor. add suppressor trna molecules to the cell. mutate or remove the shine-dalgarno sequence on the mrna.

The correct answer is "Mutate or remove the Shine-Dalgarno sequence on the mRNA".

Explanation:

The Shine-Delgarno sequence is a fragment of bacterial and archaeal messenger RNA that helps to recruit the messenger RNA to the ribosome to initiate protein synthesis by translation. Mutating  or removing the Shine-Dalgarno sequence on the mRNA will prevent translation of a particular prokaryotic mRNA. Therefore, this is a reasonable experimental strategy to achieve this effect without targeting the ribosome, but the prokaryotic mRNA.