Peter mitchell's proposal that electron transport and atp synthesis are coupled by a proton gradient across the inner mitochondrial membrane is known as the hypothesis.

Chemiosmotic coupling hypothesis

Explanation:

Chemiosmotic coupling hypothesis.

The coupling of oxidation with phosphorylation is termed oxidative phosphorylation.

The Chemiosmotic hypothesis state that electron transport chain and ATP synthesis are coupled by a proton gradient across a semi permeable membrane. The transport of protons from inside to outside of inner mitochondrial membrane is accompanied by the generation of a proton gradient across the membrane.

Protons (H+ ions) accumulate outside the membrane, creating an electrochemical potential difference. This proton motive force drives the synthesis of ATP by ATP synthase complex.

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