What type of mutation occurred for mutated sequence #1 and what was the result?

substitution --silent mutation

addition -- frameshift

deletion --missense

substitution -- missense

Addition type of mutation occurred for mutated sequence and Frameshift  was the result

Explanation:

Deletion, insertion happens in frameshift mutation. In this process bases are that are either subtracted or added and not divisible by three. When nucleotides replaced another frameshift, mutation don’t include the substitution.  

It Is the most deleterious change to the coding sequence of protein. It has capability for leading a premature end to the translation of mRNA and also formation of extended polypeptide. It is also called framing error  

it has one origin of replication, but it proceeds in two directions - d)

i think the answer would be d