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Biology, 15.01.2020 21:31 yasmimyamamoto2015

Rosiglitazone is an antidiabetic drug meant to target adipose cells, enhancing insulin effects. the drug mimics the fatty acid metabolites that bind to a nuclear receptor found mostly in fat, liver, and a few other tissues. cortisone is a type of glucocorticoid mimic that binds to a nuclear receptor, activating the receptor's transcriptional regulatory function. the ligand-activated receptor binds coregulatory proteins, and the protein complex targets gene transcription involved with inflammation. which of the following statements about these two drugs best describe their mechanism of action? choose one or more: a. rosiglitazone will bind to its receptor (peroxisome proliferator-activated receptor), and the receptor- b. zinc fingers bind at the top of rosiglitazone receptor dimers as a stabilizer, allowing the alpha helical c. receptor dimers with bound cortisone bind to the dna target using a zinc finger to bind to an inverted d. cortisone and rosiglitazone form heterodimers with the receptor in a head-to-tail fashion to regulate ligand complex can bind to the rxr receptor in a head-to-tail fashion. recognition strand to bind into the minor groove of the target dna. repeat that must be at least partially palindromic to be recognized. gene activity.

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