Which of the following statements best predicts the efforts of a loss of function of the insulin receptor's intracellular domain?

The storage of GLUT4 in vesicles inside the cell will increase.

Explanation:

Completed question

The insulin receptor is a transmembrane protein that plays a role in the regulation of glucose homeostasis. The receptor’s extracellular domain binds specifically to the peptide hormone insulin. The receptor’s intracellular domain interacts with cellular factors. The binding of insulin to the receptor stimulates a signal transduction pathway that results in the subcellular translocation of GLUT4, a glucose transport protein that is stored in vesicles inside the cell. A simplified model of the insulin receptor–signaling pathway is shown in Figure 1.

QUESTION 10

From the question above , the loss of the insulin  intracellular  receptors  will lead to accumulation of GLUT 4 transporters in the cell vesicles.Since it is the binding  of Insulin  with the receptors that stimulates the mobility of GLUT 4, as subcellular translocation in the cells  therefore the loss of these intracellular receptors will lead to aggregation of the GLUT 4 transporters, since subcellular translocation has  stopped.

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