What happpens when there is an excessive consumption of erythrocytes by macrophages?

When there is excess erythrocyte breakdown, the breakdown product Bilirubin will accumulate in the blood and it will cause jaundice in patient characterized by the yellowish skin. It indicated the severe liver damage caused by bilirubin.

what's the

the sugar-phosphate backbone forms the structural framework of nucleic acids, including dna and rna. this backbone is composed of alternating sugar and phosphate groups, and defines directionality of the molecule.