Researchers can manipulate the genes of a mouse so that a single gene in a single tissue either produces an inactive protein (a knockout mouse) or produces a protein that is always (constitutively) active. What effects on metabolism would you predict for mice with these genetic changes?

1) The genetic changes can lead to a reduction in the capacity of the mice to move glycogen at its branches points and lowers blood glucose levels between meals.

2) Genetic changed can lead to a decrease in the capacity to lower blood glucose due to the knock out of the hexokinase gene leading to elevated levels in the bloodstream.

(c) A knockout of FBPase2 will result in elevated levels of fructose-2,6-bisphosphate in

liver favoring the glycolytic pathway and inhibiting gluconeogenesis by the decrease of fructose 1,6-

bisphosphatase-1 activity

(d) An active FBPase-2 will now favor gluconeogenesis and this inhibits glycolysis. I.e. a decrease in PFK-1 activity while increasing FBPase-1 activity simultaneously.

is in the form atp or adenosine triphosphate

answers are:

lysogenic     viral dna merges with host cell dna

lysogenic     no symptoms

lytic               viral dna takes over

lysogenic     virus does not destroy host cell

lytic               virus destroys host cell

lytic               induces symptoms of viral infection

lysogenic       cell reproduces and spreads provirus