Sickle-cell anemia results from a point mutation in the HBB gene. The mutation results in the replacement of an amino acid that has a hydrophilic R-group with an amino acid that has a hydrophobic R-group on the exterior of the hemoglobin protein. Such a mutation would most likely result in altered .

properties of the molecule as a result of abnormal interactions between the adjacent molecules.

Explanation:

Hemoglobin is responsible for the transportation of oxygen throughout the body.It is made up of two subunits: alpha globins and beta globin. Beta-hemoglobin is created from the genetic information found on the HBB gene.A single point mutation in beta globin results in the replacement of hydrophophilic amino acid(glutamate) with hydrophobic amino acid(valine) at the sixth position.This result in the formation of mutant beta globin which along with alpha globin forms hemoglobin S also known as HbS. This results in the formation of deformed red blood cells or 'sickle' cells.

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b is the best answer for this question.