What is the effect of defective or missing N-acetylglucosamine phosphotransferase on lysosomal protein sorting?

The deficiency in this enzyme causes that it begins erroneously label other enzymes. Because the activating proteins are not properly labeled, they escape into spaces outside the cell and do not disintegrate substances inside the cells, that is, lysosomes cannot perform their function correctly. This causes waste products, which must include carbohydrates, lipids and proteins, accumulate in specific masses as inclusion bodies.

meteorologists would compare a new weather map with one 24 h old to see how fast a front is moving.