The following the DNA sequence is a small part of the coding (nontemplate) strand from the open reading frame of β-hemoglobin gene. Given the codon chart listed below, what would be the effect of a mutation that deletes the G at the beginning of the DNA sequence?

The reading frame of the sequence would shift, causing a change in the amino acid sequence after that point.

Explanation:

DNA sequencing is important to apply to the human genome. It allows scientists to sequence genes and genomes. Since there is a limit to how many bases can be sequenced in one experiment, larger DNA molecules - as mentioned - have to be 'broken' into smaller fragments before they can be sequenced and re assembled. The normal allelic variant is 1600 base pairs (bp) long and contains three exons. The order of the genes in the beta-globin cluster is 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.

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