Individuals who are affected by Sickle Cell Anemia have a mutation which leads to the production of valine instead of glutamic acid in a specific gene. The change in codons is shown as GAG to GTG. This is a mutation.

silent

nonsense

missense

frameshift

missense

Explanation:

Missense mutation is a type of mutation in which there is a change in a single nucleotide in a DNA sequence. It is a point mutation because only one single nucleotide is substituted or replaced by another. This change in a single nucleotide in a DNA sequence results to a change in the mRNA sequence produced from the DNA and this will lead to the incorporation of a wrong amino acid in the polypeptide chain of the protein. Missense mutation leads to a change in one codon in an mRNA which will lead to the production of a protein with an amino acid sequence that is different from the original protein. A missense mutation often leads to the production of a nonfunctional protein

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