If cortisol levels increase what happens to IGA levels

Due to an inhibitory effect of cortisol on the immune system and some proteins, if cortisol levels increase IgA levels decrease.

Explanation:

Cortisol is produced in the cortex of the adrenal gland and is a hormone that acts on the body's metabolism as well as inhibiting the inflammatory response of the immune system.

One of the known effects of cortisol is the inhibition of the secretory immunoglobulin A (IgA), the main one responsible for acting as a barrier against pathogenic microorganisms, at the level of the intestinal mucosa.

The inhibition of IgA by cortisol is not direct, but is mainly due to an inhibition of the protein that forms it, so that when cortisol levels increase, IgA levels decrease.

Learn more:

Cortisol effects link

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