How does the muscle become fatigued?

Explanation:

when the functionality capacity of a muscle  over time is being reduced, then the muscle is said to be fatigued.  take for instance before experiencing muscle fatigue at the beginning of exercise you feel agile and very active, but overtime you begin to discover weakness in your muscles. muscle fatigue can be as a result of exercise or health conditions.

Muscle fatigue can occur anywhere in the body. here are some causes of muscle fatigue

you are certainly talking about this picture:

a: is the label of the white square, it is showing the  replication fork, formed by helicase (d) ==> so it is the site of dna separation and replication 

b: is a new dna brand that is following directly the replication fork, so it is continuous ==> built continuously from 5' to 3

c: dna polymerase cannot replicate dna on its own, it needs the of their proteins, and one of them plays the role of a clamp which fixes  the dna with the dna template and increases  the processivity of the enzyme. ==>   stops polymerase from falling off the  template.

d: is the enzyme responsible for forming the replication fork (helicase) ==> unwinds and separates dna into two strands

e: is the delayed strand, it is built  in the opposite sense of the helicase, so dna will be built in fragments ==> built  fragments from 5' to 3 joins

and finally f: is the enzyme that builds  the new dna strand (dna polymerase) ==>   adds nucleotides to make a new dna helix.

credit: gradman555p98x9p

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examples of nucleic acids are deoxyribonucleic acid (dna) and ribonucleic acid (rna).