What would be the effect of a mutation in the trp aminoacyl trna synthetase that eliminated the trna binding site?

The aminoacyl Trp tRNA would not be produced.

Explanation:

Aminoacyl tRNA synthetase is the enzyme which bonds aminoacids to tRNA by binding the tRNA bindng site. This bond requires energy from cleavage of ATP which is very unstable and it can release amino acid at the ribosome easily.

As a mutation in the trp aminoacyl trna synthetase occurs resulting in eliminatio of tRNA binding site, the aminoacyl TRP tRNA would not be produced.