There are many well-known mutant forms of Hb. These forms are usually named after the region where they are first identified. Hb 'Philly' is a form of hemoglobin that is destabilized by having an F substitute for a Y in the alpha-subunits. The Y normally participates in the hydrogen-bonded network that helps to knit together the alpha1-beta1 interface. Would we say that this mutation destabilizes 1', 2', 3' or 4' structure? Pick one (the best answer) and explain why F causes this problem.

He did not infringe upon the policy making powers that he felt the constitution gave congress. but the determination of foreign policy became preponderantly a presidential concern. when the french revolution led to a major war between france and england, washington refused to accept entirely the recommendations of either his secretary of state thomas jefferson, who was pro-french, or his secretary of the treasury alexander hamilton, who was pro-british. rather, he insisted upon a neutral course until the united states could grow stronger. which provides the best objective summary of this excerpt? president washington made a good choice when he decided not to accept the recommendations of his advisors and instead insisted that the united states stay neutral during the war between france and england as president, washington believed that the united states should remain neutral in foreign policy even though he had advisors who recommended that he take sides during the war between france and england. washington did not make policy decisions during his presidency because he did not want to interfere with the policy-making powers that the constitution gave congress. washington refused to accept entirely the recommendations of either his secretary of state thomas jefferson, who was pro-french, or his secretary of the treasury alexander hamilton, who was pro-britis