Summation happens whenever muscle twitches occur at such high frequencies that calcium cannot be removed from the cytosol as rapidly as it is released. If sustained at a high enough frequency, summation could lead to a condition known as (also a term that also refers to a condition in which bacterial toxins cause inappropriate motor neuron stimulation).

Twitch Summation

Explanation:

If sustained at a high enough frequency, summation could lead to a condition known as tetanus

Tetanus is also known as lockjaw which is a serious infection caused by Clostridium tetani This bacterium produces a toxin that affects the brain and nervous system, leading to stiffness in the muscles,if Clostridium tetani spores are deposited in a wound, the neurotoxin interferes with nerves that control muscle movementSummation occurs as successive stimuli are added together to produce a stronger muscle contraction resulting in greater tension Tetanus results into prolonged contraction without relaxation and results from repeating stimulation before the muscle has a chance to relax at all(high enough frequency condition)