A chromosomes has the following segments, where  represents the centromere: M N O  P Q R S T Give the chromosome sequences that would result from the following mutations: a. Deletion of MN b. Pericentric inversion of NOP c. Inversion of RS, followed by tandem duplication of QRST

a. O | | PQRST

b. MP | | ONQRST

c. MNO | | PQSRTQRST

Explanation:

Deletion of MN: this refers to the removal of the MN segment from the seuence. thus we will have:

MNO | | PQRST - O | | PQRST

Pericentric inversion of NOP: this is a type of chromosomal rearrangement in which the order of sequence of changed through a 180 degrees orientation and this involves the centromere. thus, we will have

MNO | | PQRST - MP | | ONQRST

Inversion of RS: this does not include the centromere and is called a paracentric inversion.

MNO | | PQRST - MNO | | PQSRT

then followed by tandem duplication of QRST. Thus we will have:

MNO | | PQSRTQRST

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