The human disease beriberi is caused by a deficiency of thiamine in the diet. People with severe beriberi have higher than normal levels of pyruvate in their blood and urine. Explain this observation in terms of specific enzymatic reaction(s).

Thiamine

Explanation:

Thiamine also known as Vitamin B1 is essential for the synthesis of the cofactor thiamine pyrophosphate (TPP)Pyruvate decarboxylation occurs in matrix of mitochondria and is an irreversible reaction catalysed by a multienzyme complex called pyruvate dehydogenase (PDH) complexPDH complex consists of three different enzymes and require five coenzymes TPP is the coenzyme of pyruvate dehydrogenase, which is concerned with the oxidative decarboxylation of pyruvate and generation of acetyl CoACoA and lipoic acid are coenzymes of dihydrolipoyl transacetylase or transferase which is concerned with condensation of acetyl group with coenzyme A and produce acetyl CoA NAD+ and FAD are coenzymes of dihydrolipoyl dehydrogenase which is concerned with oxidation of lipoic acid and transfer electrons from lipoic acid to NAD+ via FADWithout  TPP pyruvate dehydrogenase complex cannot convert pyruvate into acetyl-CoA, so the  pyruvate produced by glycolysis accumulates

C) reflection (i also looked up the other choices just to make sure)

Essential for a scientist to do for credibility

evidence and logical support is essential for a scientist to do in order to maintain credibility. this is because no one can believe without any logic and without any evidence.hence a scientist can maintain credibility by proving himself and by answering logically so experiments prove very beneficial. logical hypothesis give conclusion which is acceptable. therefore, there are two main factors to maintain credibility by a scientist is evidence and logical support.