A mutation takes place in a protein-coding gene that changes one codon resulting in a single amino acid replacement. Which type of replacement is least likely to result in a disruption of protein structure and function?
a) a hydrophobic amino acid to a hydrophilic amino acid
b) a polar amino acid to a hydrophobic amino acid
c) an acidic amino acid to a basic amino acid
d) a hydrophilic amino acid to a hydrophobic amino acid
e) a polar amino acid to a polar amino acid
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