How can substances be transported across a membrane against their concentration gradient?

To move substances against a concentration or electrochemical gradient, a cell must use energy.

Explanation:

This occurs because During active transport, substances move against the concentration gradient from an area of low concentration to an area of high concentration which is a  “active” progress which requires the use of energy (usually in the form of ATP). It is the opposite of passive transport.

"1. it should be, it has been for about 20 years, and it's really not much different in the end than breeding animals to have particular traits. there are always concerns about genetically engineered animals/plants affecting the environment in unexpected negative ways, but i can't think of an example where the fears didn't turn out to be baseless.  

first, as you point out, it would be a great advance in pharmacology, to be able to tailor drugs and their doses to me. the pros involve better medical treatment. the cons involve privacy issues like insurance companies denying coverage to people with genetic risk factors. looking at dna markers wouldn't affect the frequency of genetic diseases, but it would allow detection of them earlier. and ok, actually i suppose that if people used this information to avoid having children with genetic diseases, some might decrease in frequency."