You are interested in cell-size regulation and discovering that signaling through a GPCR called ERC1 is important in controlling cell are in embryonic rat cells. The G protein downstream of ERC1 activates adenylyl cyclase, which ultimately leads to the activation of PKA. The discover that cells that lack ERC1 are 15% smaller than normal cells, while cells that express a mutant, constitivity .. PKA are 15% larger than normal cells.
1. Given these results, which of the following treatments to eukaryotic rate cells should lead to smaller cells?
a. Addition of a drug that causes cyclic AMP phosphodiesterase to be hyperactive
b. Addition of a drug that mimics the ligands of ERC1
c. Addition of a drug that prevents GTP hydrolysis by G
d. Addition of a drug that activates adenylyl cyclase