How is the structure of kinesin related to its function? How is the structure of kinesin related to its function? Kinesin has a tail region that binds to vesicles and two heads that can attach to microtubules. Kinesin has two intertwined polypeptides that make up the stalk and enable it to contract and shorten. Kinesin has two heads to attach to the vesicle being moved and a tail region that attaches to microtubules. The kinesin tail has an ATP binding site to fuel its activities.