Why do cats get "high" off of catnip??

chemical reaction

Explanation:

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Nepetalactone, one of catnip's volatile oils, enters the cat's nasal tissue, where it is believed to bind to protein receptors that stimulate sensory neurons. These cells, in turn, provoke a response in neurons in the olfactory bulb, which project to several brain regions including the amygdala (two neuronal clusters* in the midbrain that mediate emotional responses to stimuli) and the hypothalamus, the brain's "master gland" that plays a role in regulating everything from hunger to emotions.

The amygdala integrates the information flow from the olfactory bulb cells and projects to areas governing behavior responses. The hypothalamus regulates neuroendocrine responses through the pituitary gland, creating a "sexual response." That is, the cat essentially reacts to an artificial cat pheromone.

Human brains are physiologically different from cat brains and people do not react to catnip by getting "high." Native Americans, however, once used catnip for the uncontrollable cries of infant colic. It also serves as a mild sedative in some herbal teas. In alternative medicine circles, catnip is commonly recommended by herbalists to lessen migraine headaches and to relieve cramps, gas, indigestion, insomnia, nervousness and anorexia, or as an herbal paste to reduce swelling associated with arthritis and soft tissue injury.

explanation:

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