(d) Researchers discovered a strain of C. parvum that expresses a functional variation of the lactate dehydrogenase gene. A DNA sequence comparison showed that the variant differs from the normal sequence in the region that codes for the enzyme’s allosteric site. Predict the effect of FX11 treatment on C. parvum cells that express this variant of lactase dehydrogenase. Provide reasoning to support your prediction. Explain how gossypol and FX11 might be used as drugs to treat C. parvum infections in humans without negatively affecting human cells.

Changing the allosteric site would definitely impact the sensitivity of the blocker, and we can not understand precisely how it is owing to our lack of awareness of the specific adjustments and the FX11 layout.

Explanation:

The move would most likely reduce affinity, and FX11 will no longer be as successful as inhibiting C. Growth of parvum. An inhibitor may reach an allosteric site since the site has some sizes and operational classes that precisely match the shape and operational categories of the inhibitor, which is how the association is obtained if the shape is modified and the inclination is affected.

Such chemicals can be used as human drugs because the mechanism we 're disrupting isn't that normal in human cells, we 're talking about lactic fermentation. C.parvum is a parasite that is present in the digestive tract, and these areas do not appear to experience aerobic glycolysis. The material that undergoes this process under other conditions is muscle tissue. It is possible that the absorbed drug can penetrate the bloodstream and touch other organs, and we would recommend that clinicians avoid exercise during this drug therapy.

a unit of heredity that is transferred from a parent to offspring and is held to determine some characteristic of the offspring.

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